Sewall Wright ranks among the most influential figures in the field of population genetics during the 20th century, and made important contributions to biostatistics, biometrics, and evolutionary theory. These papers contain much of Wright's professional correspondence, scattered research notes, and drafts of a small number of papers.

The James V. Neel Papers document nearly every phase of the career of one of the founders of human population genetics in the United States. Neel was particularly thorough and organized, and retained virtually all of his significant scientific correspondence, committee reports, minutes of meetings, and drafts of manuscripts. The collection also includes data collected during Neel's work among the Xavante, Yanomanö and other indigenous populations. In a career that spanned the period from the late work of Thomas Hunt Morgan and Charles B. Davenport to the contemporary world of molecular genetics and nucleic acids, Neel knew, worked with, and corresponded with many of the most influential 20th century practitioners of genetics. The collection begins in earnest in 1943, after Neel had decided to focus on human genetics. Neel's work with Drosophila and none of his Drosophila manuscripts are found in the collection.

The Papers of Curt Stern include extensive correspondence, lectures (1920s-1970s, 1.5 boxes), autobiographical material, articles, zoological course notes, photographs, etc. Stern's various areas of scientific interest are documented in the collection: the chromosome theory of heredity, role of gene mutation and chromosome rearrangements in evolution, action and interaction of genes during individual development, and particularly his contribution to the development of human genetics as a discipline (centered on his popular and influential book, Principles of Human Genetics, 1949, 1960, 1973). Both his career in Germany and the United States is documented in his correspondence. After studying with T. H. Morgan at Columbia University on a Rockefeller Foundation Fellowship (1924-1926), Stern returned to Richard Goldschmidt's lab at the Kaiser-Wilhelm Institute (1926-1932). There is material of note in the collection concerning this period when Stern helped to establish the cytological basis of crossing over. After a short stay at the California Institute of Technology in 1932, Stern's temporary residence in the U. S. became permanent, and his later career at the University of Rochester, 1933-1947 (Chairman, Department of Zoology) and at the University of California, Berkeley, 1947-1970 (there is abundant material on the Department of Zoology) is covered in the collection. There is other material on: American Association for the Advancement of Science Inter-Society Committee on Science Foundation Legislation, 1946-1947; American Society of Human Genetics (Pres., 1957); Atomic Energy Commission (Advisory Committee for Biology and Medicine, 1950-1955); Genetics (journal); Oak Ridge National Laboratory (Advisory Committee for Biology, 1955-1968); and the Rockefeller Foundation. Stern's correspondence with friends and colleagues in Germany, England, and the U. S., during the 1920s-1930s, is of particular note as it documents not only the developments in genetics and the institutional and administrative networks supporting research, but it also offers general comments and observations on science, Germany, and politics. The photographs (2 boxes) include pictures of many prominent geneticists and scientists.